Subutex vs Suboxone
These two medications are both approved by the FDA for the treatment of opioid use disorder. Which is right for you?
What is the difference between Suboxone and Subutex?
Subutex and Suboxone are both sublingual medications (dissolved under the tongue) that use buprenorphine to treat opioid addiction. The difference is in their formulations. Suboxone contains both buprenorphine and naloxone, while Subutex contains buprenorphine only.
Suboxone (buprenorphine/naloxone) FAQs
Suboxone is a brand name for an FDA-approved medication (buprenorphine/naloxone) used to treat opioid addiction. Other brand names include Zubsolv and Bunavail, and generic options are also available. Buprenorphine/naloxone is endorsed by the Substance Abuse and Mental Health Service Administration as an effective method of treatment for opioid addiction treatment.
Suboxone (buprenorphine/naloxone) helps to alleviate the brain’s dependence on opioids, like heroin, fentanyl, and other prescription pain relievers, while also reducing withdrawal symptoms and cravings. Suboxone (buprenorphine/naloxone) is part of a group of interventions called medication-assisted treatment used to treat opioid use disorder.
How does Suboxone (buprenorphine/naloxone) work?
Suboxone (buprenorphine/naloxone) is a medication used to sustain recovery from opioid use disorder. It is called a partial opioid agonist, meaning it works in a similar way to opioids by binding to opioid receptors in the brain which causes limited pleasurable effects to stop withdrawal symptoms. However, it won’t provide the “high” associated with opioids like heroin. Suboxone also contains naloxone (known by the brand name Narcan), which is an opioid antagonist meaning it blocks opioid receptors, preventing misuse.
Bottom line, Suboxone (buprenorphine/naloxone):
- Helps alleviate withdrawal symptoms
- Reduces cravings for opioids
- Prevents misuse of Suboxone and/or other opioids
- Decreases the risk of relapse
Like other medication-assisted treatments, Suboxone (buprenorphine/naloxone) is often prescribed alongside behavioral therapy, which has been found to be most effective in the treatment of opioid addiction. You can read more about the science of Suboxone (buprenorphine/naloxone) in our Health Guides.
Do I have to stop using opioids to take Suboxone (buprenorphine/naloxone)?
Yes. According to the American Society of Addiction Medicine, you will need to prepare for your first dose of medication-assisted treatment containing buprenorphine. This means stopping using opioids for a specified amount of time before you take Suboxone (buprenorphine/naloxone) in order to prevent unpleasant side effects. That time period depends on whether the opioid you have been taking is a short-acting or long-acting opioid. Generally speaking, short-acting opioids like Percocet, heroin, and Vicodin should be ceased 12-24 hours before your first dose. Longer-acting opioids, like morphine, methadone, and Oxycontin are generally discontinued 36-48 hours before your first dose of Suboxone (buprenorphine/naloxone).
The key is checking in with an experienced physician licensed to prescribe this medication, who can advise you of the appropriate time frame based on your unique medical history.
What are the side effects of Suboxone (buprenorphine/naloxone)?
Like with any medication, some people experience side effects when taking Suboxone (buprenorphine/naloxone). These may subside over time. Common side effects include:
- numbness in the mouth
- mouth redness
- dizziness
- headache
- numbness or tingling
- sleep problems
- stomach pain
- vomiting
- constipation
- drowsiness
- difficulty concentrating
- mouth pain
What form does Suboxone (buprenorphine/naloxone) come in?
Suboxone is a sublingual film, and other brands of buprenorphine/naloxone come in the form of sublingual films and tablets. It is important to allow the medication to fully dissolve under the tongue or against the cheek (not chewing or swallowing) in order to receive the full dosage, as buprenorphine is not absorbed well in the stomach or intestines.
Why is there naloxone in Suboxone?
You may have heard of naloxone under the brand name Narcan. Narcan and other naloxone-only formulations are life-saving medications that can reverse an opioid overdose almost instantly. This means that if someone has too much of an opiate in their system, naloxone will bind more strongly to those receptors, knocking them free and reversing a potentially fatal overdose.
As mentioned above, Suboxone (buprenorphine/naloxone) is taken sublingually (placed under the tongue and allowed to dissolve). This is because buprenorphine is absorbed really well under the tongue. Naloxone, however, does not absorb well sublingually. When you take Suboxone as prescribed, the naloxone is essentially doing nothing. It is only is Suboxone (buprenorphine/naloxone) is taken inappropriately that naloxone will kick in, blocking an illicit high or overdose. This is included to make Suboxone (buprenorphine/naloxone) less likely to be diverted or misused.
Subutex (buprenorphine) FAQs
Subutex contains buprenorphine only. Like Suboxone, Subutex is an FDA-approved medication that helps to treat opioid addiction.
How does Subutex work?
Subutex is a brand name for buprenorphine, which is a partial opioid agonist, meaning it works in a similar way to opioids by binding to opioid receptors in the brain which causes limited pleasurable effects to stop withdrawal symptoms. However, it won’t provide the “high” associated with opioids like heroin.
Bottom line, Subutex (buprenorphine):
- Helps alleviate withdrawal symptoms
- Reduces cravings for opioids
- Decreases the risk of relapse
Like other medication-assisted treatments, Subutex (buprenorphine) is often prescribed alongside behavioral therapy, which has been found to be most effective in the treatment of opioid addiction.
Do I have to stop using opioids to take Subutex (buprenorphine)?
Yes. According to the American Society of Addiction Medicine, you will need to prepare for your first dose of medication-assisted treatment containing buprenorphine. This means stopping using opioids for a specified amount of time before you take Subutex (buprenorphine) in order to prevent unpleasant side effects. That time period depends on whether the opioid you have been taking is a short-acting or long-acting opioid. Generally speaking, short-acting opioids like Percocet, heroin, and Vicodin should be ceased 12-24 hours before your first dose. Longer-acting opioids, like morphine, methadone, and Oxycontin are generally discontinued 36-48 hours before your first dose of Subutex (buprenorphine).
What are the side effects of Subutex (buprenorphine)?
Some of the reported side effects of taking Subutex (buprenorphine) include:
- sleep problems
- headache
- constipation
- nausea
- vomiting
- sweating
- pain
As with all side effects, they vary per person and can dissipate after a period of time taking the medication.
What form does Subutex (buprenorphine) come in?
Subutex is a sublingual pill. It is important to allow the medication to fully dissolve under the tongue or against the cheek (not chewing or swallowing) in order to receive the full dosage, as buprenorphine is not absorbed well in the stomach or intestines.
Where can I get Suboxone or Subutex?
Workit Health offers Suboxone (buprenorphine/naloxone) treatment in many states (see our map below). Workit’s telemedicine Suboxone (buprenorphine/naloxone) treatment is 100% virtual. If you aren’t in our area, learn other strategies for finding a Suboxone Clinic near you. Workit does not prescribe Subutex (buprenorphine).
To find Suboxone (buprenorphine/naloxone) or Subutex (buprenorphine) treatment in your area, the NAABT has a directory called Treatment Match which will connect you with local providers. And the Substance Abuse and Mental Health Services Administration (SAMHSA) offers a Buprenorphine Practitioner Locator.
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Medication-assisted treatment
Has my opioid use become a problem?
Take our opioid self-assessment to check on your use. This tool should not be used as a replacement for a clinical diagnosis.
Opioid Use Self-Assessment Quiz
Take our opioid self-assessment to check on your use and find out if Workit Health is right for you. This screening tool is a self-evaluation adapted from the DSM screening tool, and is designed as a self-assessment of opioid use.
Our pages are medically reviewed and fact-checked by accredited medical professionals to ensure that all statements about medical conditions, symptoms, treatments, procedures and tests, standards of care, and typical protocols are accurate and reflect current guidelines as well as the latest research. However, please remember that the information on this page is for informational purposes only and is not intended to replace or substitute for any medical or other advice. Workit Health, Inc. and its affiliated professional entities make no representations or warranties and expressly disclaim any and all liability concerning any treatment, action by, or effect on any person following the general information offered or provided on this page. If you have specific concerns or a situation arises in which you require medical advice, you should consult with an appropriately trained and qualified medical services provider.
