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Suboxone vs Methadone

These two medications are both approved by the FDA for the treatment of opioid use disorder. Which is right for you?

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By Workit Health Content Team

Medically Reviewed by Dorothy Moore, N.P.

Reviewed: November 15, 2021

What is the difference between Suboxone and methadone?

Methadone and Suboxone (buprenorphine/naloxone) are both FDA-approved medications used to treat opioid use disorder. Methadone has been used as a treatment for addiction since the 1960s. Buprenorphine has been available in addiction treatment since the early 2000s. Both have a strong body of research demonstrating that they decrease illicit opioid use, overdose deaths, and other use-related complications.

Methadone is a full opioid agonist, while buprenorphine is a partial opioid agonist. This means they affect people differently, and some people may respond better to one than the other. Both are classified as controlled substances, but in most states methadone is more strictly controlled than Suboxone (buprenorphine/naloxone).

Suboxone (buprenorphine/naloxone) FAQs

Suboxone is a brand name for an FDA-approved medication (buprenorphine/naloxone) used to treat opioid addiction. Other brand names include Zubsolv and Bunavail, and generic options are also available. Buprenorphine/naloxone is endorsed by the Substance Abuse and Mental Health Service Administration as an effective method of treatment for opioid addiction treatment.

Suboxone (buprenorphine/naloxone) helps to alleviate the brain’s dependence on opioids, like heroin, fentanyl, and other prescription pain relievers, while also reducing withdrawal symptoms and cravings. Suboxone (buprenorphine/naloxone) is part of a group of interventions called medication-assisted treatment used to treat opioid use disorder.

How does Suboxone (buprenorphine/naloxone) work?

Suboxone (buprenorphine/naloxone) is a medication used to sustain recovery from opioid use disorder. It is called a partial opioid agonist, meaning it works in a similar way to opioids by binding to opioid receptors in the brain which causes limited pleasurable effects to stop withdrawal symptoms. However, it won’t provide the “high” associated with opioids like heroin. Suboxone also contains naloxone (known by the brand name Narcan), which is an opioid antagonist meaning it blocks opioid receptors, preventing misuse.

Bottom line, Suboxone (buprenorphine/naloxone):

  • Helps alleviate withdrawal symptoms
  • Reduces cravings for opioids
  • Prevents misuse of Suboxone and/or other opioids
  • Decreases the risk of relapse

Like other medication-assisted treatments, Suboxone (buprenorphine/naloxone) is often prescribed alongside behavioral therapy, which has been found to be most effective in the treatment of opioid addiction. You can read more about the science of Suboxone (buprenorphine/naloxone) in our Health Guides.

Do I have to stop using opioids to take Suboxone (buprenorphine/naloxone)?

Yes. According to the American Society of Addiction Medicine, you will need to prepare for your first dose of medication-assisted treatment containing buprenorphine. This means stopping using opioids for a specified amount of time before you take Suboxone (buprenorphine/naloxone) in order to prevent unpleasant side effects. That time period depends on whether the opioid you have been taking is a short-acting or long-acting opioid. Generally speaking, short-acting opioids like Percocet, heroin, and Vicodin should be ceased 12-24 hours before your first dose. Longer-acting opioids, like morphine, methadone, and Oxycontin are generally discontinued 36-48 hours before your first dose of Suboxone (buprenorphine/naloxone).

The key is checking in with an experienced physician licensed to prescribe this medication, who can advise you of the appropriate time frame based on your unique medical history.

What are the side effects of Suboxone (buprenorphine/naloxone)?

Like with any medication, some people experience side effects when taking Suboxone (buprenorphine/naloxone). These may subside over time. Common side effects include:

  • numbness in the mouth
  • mouth redness
  • dizziness
  • headache
  • numbness or tingling
  • sleep problems
  • stomach pain
  • vomiting
  • constipation
  • drowsiness
  • difficulty concentrating
  • mouth pain

What form does Suboxone (buprenorphine/naloxone) come in?

Suboxone is a sublingual film, and other brands of buprenorphine/naloxone come in the form of sublingual films and tablets. It is important to allow the medication to fully dissolve under the tongue or against the cheek (not chewing or swallowing) in order to receive the full dosage, as buprenorphine is not absorbed well in the stomach or intestines.

Why is there naloxone in Suboxone?

You may have heard of naloxone under the brand name Narcan. Narcan and other naloxone-only formulations are life-saving medications that can reverse an opioid overdose almost instantly. This means that if someone has too much of an opiate in their system, naloxone will bind more strongly to those receptors, knocking them free and reversing a potentially fatal overdose. 

As mentioned above, Suboxone (buprenorphine/naloxone) is taken sublingually (placed under the tongue and allowed to dissolve). This is because buprenorphine is absorbed really well under the tongue. Naloxone, however, does not absorb well sublingually. When you take Suboxone as prescribed, the naloxone is essentially doing nothing. It is only is Suboxone (buprenorphine/naloxone) is taken inappropriately that naloxone will kick in, blocking an illicit high or overdose. This is included to make Suboxone (buprenorphine/naloxone) less likely to be diverted or misused.

Methadone FAQs

Methadone is the oldest medicine approved by the FDA to treat opioid use disorder. Despite some lingering stigma, when it is taken as prescribed, methadone is safe and effective. Methadone helps individuals achieve and sustain long-term recovery.

How does methadone work?

Methadone is a long-acting opioid agonist. It occupies and activates the opioid receptors in the brain, but does so more slowly than other opioids. In this way, therapeutic doses of methadone usually don’t produce a euphoric effect, or the “high” that fuels the dangerous using cycle of illicit opiates. Methadone reduces cravings and withdrawal symptoms, and blunts the effects of opioids.

Bottom line, methadone:

  • Helps reduce withdrawal symptoms
  • Lessens cravings for opioids
  • Decreases the risk of relapse

Do I have to stop using opioids to take methadone?

You should stop taking opioids if you are using methadone treatment. Combining the two can create a sedative effect and respiratory depression, which can be dangerous. Talk to your doctor if you take other opioids while you’re receiving methadone.

What are the side effects of methadone?

As with other medications, some people experience side effects when taking methadone. These may subside over time. Common side effects include:

  • Restlessness
  • Nausea or vomiting
  • Slow breathing
  • Itchy skin
  • Heavy sweating
  • Constipation
  • Sexual problems

What form does methadone come in?

Methadone comes in several forms. Taken daily for opioid use disorder, it is available in liquid, powder, and pill forms. It is usually taken once per day.

Transitioning from methadone to Suboxone

If you want to switch from methadone to buprenorphine, most doctors recommend that you taper down to as low a dose as possible before making the switch—at least 30 milligrams. Experts have noted that some patients may need to taper to an even lower dose. This can be frustrating for patients on high doses of methadone because tapering comfortably can take several months to a year (or longer) depending on your dose and how well you tolerate the decrease. But it’s important to be patient with this process. Trying to decrease your dose too quickly will only increase your likelihood of relapse, and cause you unnecessary discomfort.

Do not attempt to switch from methadone to buprenorphine without medical guidance.

When you reach a low enough dose of methadone, your clinician will guide you in inducting on a low dose of Suboxone (buprenorphine/naloxone). When using this method, your provider will direct you to take your (low) beginning dose, wait one hour to see how you tolerate it, and then take your next dose at the same amount if there are no side effects. This process is important, because there may still be enough methadone in your system to trigger precipitated withdrawal. The small dose of buprenorphine will limit the intensity of these effects.

Are Suboxone (buprenorphine/naloxone) and methadone compatible with telehealth?

Suboxone (buprenorphine/naloxone)treatment is available via telehealth. Clinicians must be licensed and trained through the DEA to prescribe buprenorphine/naloxone, but they can do so via telehealth after a thorough evaluation. Most states also require drug testing, which can be done virtually. The medication itself is e-prescribed to a local pharmacy.

Traditionally, methadone must be taken at approved clinics (called Opioid Treatment Programs). As of February 2024, federal restrictions make methdaone more accessible, allowing increased flexibility for some people to receive a month’s supply of methadone at a time instead of going to a clinic daily and allowing methadone to be prescribed via telehealth from an OTP. Workit Health does not prescribe methadone.

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1. Buprenorphine. Substance Abuse and Mental Health Services Administration (SAMHSA). Accessed November 2021.

2. Davis, C. S., & Samuels, E. A. (2021). Continuing increased access to buprenorphine in the United States via telemedicine after COVID-19. The International Journal on Drug Policy, 93: 102905.

3. Barnett, P.G., Rodgers, J.H., & Bloch, D.A. (2001). A meta-analysis comparing buprenorphine to methadone for treatment of opiate dependence. Addiction, 96: 683-690.

4. Whelan, P.J. & Remski, K. (2012). Buprenorphine vs methadone treatment: A review of evidence in both developed and developing worlds. J Neurosci Rural Pract, 03(01): 45-50.

5. Does Suboxone show up on a drug test? Accessed November 2021.

6. Fiellin, D. A., Moore, B. A., Sullivan, L. E., Becker, W. C., Pantalon, M. C., Chawarski, M. C., Barry, D. T., O’Connor, P. G., & Schottenfeld, R. S. (2008) Long-Term Treatment with Buprenorphine/Naloxone in Primary Care: Results at 2–5 Years, American Journal on Addictions, 17:2, 116-120,

7. Methadone. Substance Abuse and Mental Health Services Administration (SAMHSA). Accessed November 2021.

8. Joseph, H., Stancliff, S., & Langrod, J. (2000). Methadone maintenance treatment (MMT): a review of historical and clinical issues. Mt Sinai J Med. 67:5-6, 347-364.

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